Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets

Virology. 2018 Oct;523:22-26. doi: 10.1016/j.virol.2018.07.028. Epub 2018 Jul 31.

Abstract

Live bird market surveillance for avian influenza viruses in Cambodia in 2015 has led to the detection of two 7:1 reassortant influenza A(H5N1) clade 2.3.2.1c viruses. These reassortant strains, designated A/duck/Cambodia/Z564W35M1/2015 and A/chicken/Cambodia/Z850W49M1/2015, both contained a single gene (PB1 and matrix gene, respectively) from concurrently circulating A(H9N2) influenza viruses. All other viral genes from both isolates clustered with A(H5N1) clade 2.3.2.1 viruses. Continued and prolonged co-circulation of influenza A(H5N1) and A(H9N2) viruses in Cambodian live bird markets may present a risk for the emergence of novel influenza reassortant viruses with negative agricultural and/or public health implications.

Keywords: A(H5N1); A(H9N2); Cambodia; Influenza; Live bird markets; Reassortment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cambodia / epidemiology
  • Chickens
  • Ducks
  • Epidemiological Monitoring
  • Gene Expression
  • Influenza A Virus, H5N1 Subtype / classification
  • Influenza A Virus, H5N1 Subtype / genetics*
  • Influenza A Virus, H5N1 Subtype / isolation & purification
  • Influenza A Virus, H5N1 Subtype / metabolism
  • Influenza A Virus, H9N2 Subtype / classification
  • Influenza A Virus, H9N2 Subtype / genetics*
  • Influenza A Virus, H9N2 Subtype / isolation & purification
  • Influenza A Virus, H9N2 Subtype / metabolism
  • Influenza in Birds / epidemiology*
  • Influenza in Birds / transmission
  • Influenza in Birds / virology
  • Phylogeny
  • Poultry Diseases / epidemiology*
  • Poultry Diseases / transmission
  • Poultry Diseases / virology
  • Reassortant Viruses / classification
  • Reassortant Viruses / genetics*
  • Reassortant Viruses / isolation & purification
  • Reassortant Viruses / metabolism
  • Viral Matrix Proteins / genetics
  • Viral Matrix Proteins / metabolism
  • Viral Proteins / genetics
  • Viral Proteins / metabolism

Substances

  • M1 protein, Influenza A virus
  • Viral Matrix Proteins
  • Viral Proteins
  • influenza virus polymerase basic protein 1