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Observational Study
. 2018 Oct;38(10):1344-1352.
doi: 10.1038/s41372-018-0183-y. Epub 2018 Aug 3.

Higher Intake of Coagulase-Negative Staphylococci From Maternal Milk Promotes Gut Colonization With mecA-negative Staphylococcus Epidermidis in Preterm Neonates

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Observational Study

Higher Intake of Coagulase-Negative Staphylococci From Maternal Milk Promotes Gut Colonization With mecA-negative Staphylococcus Epidermidis in Preterm Neonates

Hiie Soeorg et al. J Perinatol. .

Abstract

Objective: We aimed to determine factors associated with gut colonization of preterm neonates with coagulase-negative staphylococci (CoNS) from maternal milk (MM).

Study design: CoNS isolated from weekly collected stool and MM of hospitalized preterm (n = 49) and healthy term neonates (n = 20) were genotyped. Colonization-related factors were determined by Cox proportional hazards regression.

Result: Gut colonization with mecA-negative Staphylococcus epidermidis from MM was less prevalent (40.8% vs. 95%) and delayed (median age 15.5 vs. 2 days) in preterm compared with term neonates. Enhanced colonization was associated with higher intake of CoNS from MM (hazard ratio (95% confidence interval) 1.006 (1.00-1.01) for 106 colony-forming units), lower proportion of mecA-positive predominant NICU strains in gut (0.09 (0.01-0.49) for 1%) and lower incidence of late-onset CoNS sepsis (5% vs. 34% in those without colonization).

Conclusion: Enteral feeding with larger proportion of unpasteurized MM and limiting spread of predominant strains may promote colonization with CoNS from MM.

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