Vielopsides A-E, five new guaiane-type sesquiterpenoid dimers from Xylopia vielana

Yang-Guo Xie; Guo-Jing Wu; Tao-Fang Cheng; Sheng-Lan Zhu; Shi-Kai Yan; Hui-Zi Jin; Wei-Dong Zhang

doi:10.1016/j.fitote.2018.07.020

Vielopsides A-E, five new guaiane-type sesquiterpenoid dimers from Xylopia vielana

Fitoterapia. 2018 Oct:130:43-47. doi: 10.1016/j.fitote.2018.07.020. Epub 2018 Aug 1.

Authors

Yang-Guo Xie¹, Guo-Jing Wu¹, Tao-Fang Cheng¹, Sheng-Lan Zhu¹, Shi-Kai Yan¹, Hui-Zi Jin², Wei-Dong Zhang³

Affiliations

¹ Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
² Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: kimhz@sjtu.edu.cn.
³ Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address: wdzhangy@hotmail.com.

PMID: 30076886
DOI: 10.1016/j.fitote.2018.07.020

Abstract

Five new guaiane-type sesquiterpenoid dimers vielopsides A-E, connecting patterns through two direct CC bonds (C-2 to C-2', C-4 to C-1'), were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOE analysis, the Cu Kα X-ray crystallographic and circular dichroism (CD) experiment. Among them, compound 5 showed moderate activity IC₅₀ values of 33.8 μM on NO production in RAW 264.7 macrophages.

Keywords: Sesquiterpenoid dimers NO; Xylopia vielana.

MeSH terms

Animals
China
Mice
Molecular Structure
Nitric Oxide / metabolism
Phytochemicals / isolation & purification*
Phytochemicals / pharmacology
Plant Roots / chemistry
RAW 264.7 Cells
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Xylopia / chemistry*

Substances

Phytochemicals
Sesquiterpenes
Nitric Oxide