Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

Keisuke Migita; Yu Matsuzaki; Kohei Koga; Taichi Matsumoto; Kenichi Mishima; Shuji Hara; Kenji Honda

doi:10.1016/j.jphs.2018.05.009

Involvement of GABA_B receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

J Pharmacol Sci. 2018 Jun;137(2):233-236. doi: 10.1016/j.jphs.2018.05.009. Epub 2018 Jun 7.

Authors

Keisuke Migita¹, Yu Matsuzaki², Kohei Koga³, Taichi Matsumoto⁴, Kenichi Mishima², Shuji Hara⁴, Kenji Honda⁵

Affiliations

¹ Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan. Electronic address: migitak@fukuoka-u.ac.jp.
² Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan.
³ Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
⁴ Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan.
⁵ Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan. Electronic address: hondak@fukuoka-u.ac.jp.

PMID: 30078433
DOI: 10.1016/j.jphs.2018.05.009

Abstract

The role of the GABA_B receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABA_B receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats. Activation of the GABA_B receptor injected by a GABA_B receptor agonist baclofen into the ACC attenuated mechanical hypersensitivity in partial sciatic nerve ligation (PSNL) rats. Co-microinjection of CGP35348 with a muscarinic M1 receptor agonist McN-A-343 into the ACC significantly inhibited McN-A-343-induced antihypersensitivity in PSNL rats. These results suggest that the GABA_B receptor in the ACC contributes to mechanical hypersensitivity and is involved in muscarinic M₁ receptor-mediated antihypersensitivity.

Keywords: Anterior cingulate cortex; GABA(B) receptor; Partial sciatic nerve ligation model.

MeSH terms

Animals
Baclofen / therapeutic use
Disease Models, Animal
GABA-B Receptor Agonists / therapeutic use
Gyrus Cinguli*
Hyperalgesia / drug therapy
Hyperalgesia / etiology
Hyperalgesia / genetics*
Ligation
Male
Neuralgia / drug therapy
Neuralgia / genetics*
Rats, Wistar
Receptor, Muscarinic M1 / physiology
Receptors, GABA-B / physiology*
Sciatic Nerve*

Substances

GABA-B Receptor Agonists
Receptor, Muscarinic M1
Receptors, GABA-B
Baclofen