A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

Nature. 1986 Apr 3-9;320(6061):415-21. doi: 10.1038/320415a0.

Abstract

A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Transformation, Viral*
  • Gene Products, gag
  • Genes
  • Molecular Weight
  • Oncogene Proteins, Viral / genetics*
  • Oncogenes*
  • Protein Kinases / genetics*
  • Proto-Oncogenes
  • Recombination, Genetic
  • Retroviridae / genetics*
  • Retroviridae Proteins / genetics
  • Sarcoma Viruses, Feline / genetics*

Substances

  • Gene Products, gag
  • Oncogene Proteins, Viral
  • Retroviridae Proteins
  • Protein Kinases

Associated data

  • GENBANK/X03711