Exploiting natural regulation

doi:10.7554/eLife.39664

Comment

. 2018 Aug 6:7:e39664.

doi: 10.7554/eLife.39664.

Exploiting natural regulation

Catherine Proenza^{1

2}

Affiliations

¹ Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States.
² Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, United States.

PMID: 30080138
PMCID: PMC6078491
DOI: 10.7554/eLife.39664

Comment

Exploiting natural regulation

Catherine Proenza. Elife. 2018.

. 2018 Aug 6:7:e39664.

doi: 10.7554/eLife.39664.

Author

Catherine Proenza^{1

2}

Affiliations

¹ Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States.
² Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, United States.

PMID: 30080138
PMCID: PMC6078491
DOI: 10.7554/eLife.39664

Abstract

Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs.

Keywords: HCN channels; TRIP8b; allosteric regulation; cAMP; cardiac pacemaker; molecular biophysics; mouse; structural biology.

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Conflict of interest statement

CP No competing interests declared

Comment on

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Saponaro A, Cantini F, Porro A, Bucchi A, DiFrancesco D, Maione V, Donadoni C, Introini B, Mesirca P, Mangoni ME, Thiel G, Banci L, Santoro B, Moroni A. Saponaro A, et al. Elife. 2018 Jun 20;7:e35753. doi: 10.7554/eLife.35753. Elife. 2018. PMID: 29923826 Free PMC article.

Cited by

Cardiac Pacemaker Activity and Aging.
Peters CH, Sharpe EJ, Proenza C. Peters CH, et al. Annu Rev Physiol. 2020 Feb 10;82:21-43. doi: 10.1146/annurev-physiol-021119-034453. Epub 2019 Nov 22. Annu Rev Physiol. 2020. PMID: 31756134 Free PMC article. Review.
Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins.
Peters CH, Myers ME, Juchno J, Haimbaugh C, Bichraoui H, Du Y, Bankston JR, Walker LA, Proenza C. Peters CH, et al. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18079-18090. doi: 10.1073/pnas.2006238117. Epub 2020 Jul 9. Proc Natl Acad Sci U S A. 2020. PMID: 32647060 Free PMC article.
Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels.
Piantoni C, Paina M, Molla D, Liu S, Bertoli G, Jiang H, Wang Y, Wang Y, Wang Y, DiFrancesco D, Barbuti A, Bucchi A, Baruscotti M. Piantoni C, et al. Elife. 2022 Mar 22;11:e75119. doi: 10.7554/eLife.75119. Elife. 2022. PMID: 35315774 Free PMC article.

References

1. Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN. Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels. PNAS. 2012;109:7899–7904. doi: 10.1073/pnas.1201997109. - DOI - PMC - PubMed
1. Bankston JR, DeBerg HA, Stoll S, Zagotta WN. Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b. Journal of Biological Chemistry. 2017;292:17794–17803. doi: 10.1074/jbc.M117.800722. - DOI - PMC - PubMed
1. DeBerg HA, Bankston JR, Rosenbaum JC, Brzovic PS, Zagotta WN, Stoll S. Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b. Structure. 2015;23:734–744. doi: 10.1016/j.str.2015.02.007. - DOI - PMC - PubMed
1. Fisher DW, Han Y, Lyman KA, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM. HCN channels in the hippocampus regulate active coping behavior. Journal of Neurochemistry. 2018 doi: 10.1111/jnc.14539. - DOI - PMC - PubMed
1. Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Journal of Biological Chemistry. 2011;286:20823–20834. doi: 10.1074/jbc.M111.236125. - DOI - PMC - PubMed

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[1] Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN. Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels. PNAS. 2012;109:7899–7904. doi: 10.1073/pnas.1201997109. - DOI - PMC - PubMed

[2] Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN. Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels. PNAS. 2012;109:7899–7904. doi: 10.1073/pnas.1201997109. - DOI - PMC - PubMed

[3] Bankston JR, DeBerg HA, Stoll S, Zagotta WN. Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b. Journal of Biological Chemistry. 2017;292:17794–17803. doi: 10.1074/jbc.M117.800722. - DOI - PMC - PubMed

[4] Bankston JR, DeBerg HA, Stoll S, Zagotta WN. Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b. Journal of Biological Chemistry. 2017;292:17794–17803. doi: 10.1074/jbc.M117.800722. - DOI - PMC - PubMed

[5] DeBerg HA, Bankston JR, Rosenbaum JC, Brzovic PS, Zagotta WN, Stoll S. Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b. Structure. 2015;23:734–744. doi: 10.1016/j.str.2015.02.007. - DOI - PMC - PubMed

[6] DeBerg HA, Bankston JR, Rosenbaum JC, Brzovic PS, Zagotta WN, Stoll S. Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b. Structure. 2015;23:734–744. doi: 10.1016/j.str.2015.02.007. - DOI - PMC - PubMed

[7] Fisher DW, Han Y, Lyman KA, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM. HCN channels in the hippocampus regulate active coping behavior. Journal of Neurochemistry. 2018 doi: 10.1111/jnc.14539. - DOI - PMC - PubMed

[8] Fisher DW, Han Y, Lyman KA, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM. HCN channels in the hippocampus regulate active coping behavior. Journal of Neurochemistry. 2018 doi: 10.1111/jnc.14539. - DOI - PMC - PubMed

[9] Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Journal of Biological Chemistry. 2011;286:20823–20834. doi: 10.1074/jbc.M111.236125. - DOI - PMC - PubMed

[10] Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Journal of Biological Chemistry. 2011;286:20823–20834. doi: 10.1074/jbc.M111.236125. - DOI - PMC - PubMed

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Exploiting natural regulation

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Exploiting natural regulation

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Conflict of interest statement

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Full Text Sources

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