Toxic medications in Leber's hereditary optic neuropathy

Kaitlin Kogachi; Anna Ter-Zakarian; Samuel Asanad; Alfredo Sadun; Rustum Karanjia

doi:10.1016/j.mito.2018.07.007

Toxic medications in Leber's hereditary optic neuropathy

Mitochondrion. 2019 May:46:270-277. doi: 10.1016/j.mito.2018.07.007. Epub 2018 Aug 4.

Authors

Kaitlin Kogachi¹, Anna Ter-Zakarian², Samuel Asanad³, Alfredo Sadun³, Rustum Karanjia⁴

Affiliations

¹ Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA. Electronic address: kaitlin9210@gmail.com.
² Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA.
³ Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA; Doheny Eye Center, Department of Ophthalmology, David Geffen School of Medicine at UCLA, 800 South Fairmount Avenue, Suite 215, Pasadena, CA 91105, USA.
⁴ Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA; Doheny Eye Center, Department of Ophthalmology, David Geffen School of Medicine at UCLA, 800 South Fairmount Avenue, Suite 215, Pasadena, CA 91105, USA; The Ottawa Eye Institute, University of Ottawa, 501 Smyth Rd, Ottawa, ON K1H 8M2, Canada; Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada.

PMID: 30081212
DOI: 10.1016/j.mito.2018.07.007

Abstract

Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder characterized by acute bilateral vision loss. The pathophysiology involves reactive oxygen species (ROS), which can be affected by medications. This article reviews the evidence for medications with demonstrated and theoretical effects on mitochondrial function, specifically in relation to increased ROS production. The data reviewed provides guidance when selecting medications for individuals with LHON mutations (carriers) and are susceptible to conversion to affected. However, as with all medications, the proven benefits of these therapies must be weighed against, in some cases, purely theoretical risks for this unique patient population.

Keywords: Antimicrobials; Leber's hereditary optic neuropathy; Medications; Mitochondrial toxicity.

Publication types

Review

MeSH terms

Drug-Related Side Effects and Adverse Reactions*
Humans
Optic Atrophy, Hereditary, Leber / pathology*
Reactive Oxygen Species / metabolism*
Reactive Oxygen Species / toxicity*

Substances

Reactive Oxygen Species