ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors

Bioorg Med Chem Lett. 2018 Aug 15;28(15):2622-2626. doi: 10.1016/j.bmcl.2018.06.040. Epub 2018 Jun 19.


Rho kinase (ROCK) inhibitors are potential therapeutic agents for the treatment of a variety of disorders including hypertension, glaucoma and erectile dysfunction. Here we disclose a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Substitution of the 3-position of 7-azaindole led to compounds such as 37, which possess excellent ROCK inhibitory potency and high selectivity against the closely related kinase PKA.

Keywords: 7-Azaindole; Lipophilic efficiency; ROCK; Rho kinase; Solubilizing group; Structure-based design.

MeSH terms

  • Crystallography, X-Ray
  • Drug Design*
  • Indoles / chemistry*
  • Ligands
  • Protein Kinase Inhibitors / chemical synthesis
  • Protein Kinase Inhibitors / chemistry*
  • Protein Kinase Inhibitors / pharmacology*
  • Solubility
  • Structure-Activity Relationship
  • rho-Associated Kinases / antagonists & inhibitors*


  • 7-azaindole dimer
  • Indoles
  • Ligands
  • Protein Kinase Inhibitors
  • rho-Associated Kinases