mTORC1 and IRS1: Another Deadly Kiss

Amin Ardestani; Kathrin Maedler

doi:10.1016/j.tem.2018.07.003

mTORC1 and IRS1: Another Deadly Kiss

Trends Endocrinol Metab. 2018 Nov;29(11):737-739. doi: 10.1016/j.tem.2018.07.003. Epub 2018 Aug 3.

Authors

Amin Ardestani¹, Kathrin Maedler²

Affiliations

¹ University of Bremen, Centre for Biomolecular Interactions Bremen, Bremen 28359, Germany. Electronic address: ardestani.amin@gmail.com.
² University of Bremen, Centre for Biomolecular Interactions Bremen, Bremen 28359, Germany. Electronic address: kmaedler@uni-bremen.de.

PMID: 30082207
DOI: 10.1016/j.tem.2018.07.003

Abstract

Mechanistic target of rapamycin complex (mTORC)1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback loops enable adaptation to nutrient and growth factor availability and metabolic demand. In their recent study, Yoneyama et al. have identified and characterized a negative feedback loop from mTORC1 to insulin receptor substrate (IRS)1; the key component of the insulin/insulin-like growth factor (IGF) signaling pathway.

Keywords: IGF-I; IRS1; feedback loops; mTORC1; mTORC2.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Insulin / metabolism*
Insulin Receptor Substrate Proteins / metabolism*
Insulin-Like Growth Factor I / metabolism*
Mechanistic Target of Rapamycin Complex 1 / metabolism*
Signal Transduction*

Substances

Insulin
Insulin Receptor Substrate Proteins
Insulin-Like Growth Factor I
Mechanistic Target of Rapamycin Complex 1