ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis

doi:10.1038/s41419-018-0846-9

. 2018 Aug 6;9(8):839.

doi: 10.1038/s41419-018-0846-9.

ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis

Dhia Azzouz^{1

2}, Nades Palaniyar^{3

4

5}

Affiliations

¹ Program in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.
² Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
³ Program in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada. nades.palaniyar@sickkids.ca.
⁴ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. nades.palaniyar@sickkids.ca.
⁵ Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. nades.palaniyar@sickkids.ca.

PMID: 30082793
PMCID: PMC6079026
DOI: 10.1038/s41419-018-0846-9

ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis

Dhia Azzouz et al. Cell Death Dis. 2018.

. 2018 Aug 6;9(8):839.

doi: 10.1038/s41419-018-0846-9.

Authors

Dhia Azzouz^{1

2}, Nades Palaniyar^{3

4

5}

Affiliations

¹ Program in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.
² Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
³ Program in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada. nades.palaniyar@sickkids.ca.
⁴ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. nades.palaniyar@sickkids.ca.
⁵ Institute of Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. nades.palaniyar@sickkids.ca.

PMID: 30082793
PMCID: PMC6079026
DOI: 10.1038/s41419-018-0846-9

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

**Fig. 1. The key steps of UV-induced apoptosis and ApoNETosis.**
Low dose UV irradiation induces low levels of mitochondrial ROS, cytochrome c release, caspase cascade activation, and finally nuclear condensation and blebbing. On the other hand, high dose UV irradiation results in large amounts of mitochondrial ROS, cytochrome c release, and caspase cascade activation. However, p38 activation and transcriptional firing are also induced, resulting in MPO-coated NET formation and NET release.

See this image and copyright information in PMC

Cited by

Structure-preserving fixation allows scanning electron microscopy to reveal biofilm microstructure and interactions with immune cells.
Wells M, Mikesh M, Gordon V. Wells M, et al. J Microsc. 2024 Jan;293(1):59-68. doi: 10.1111/jmi.13252. Epub 2023 Dec 22. J Microsc. 2024. PMID: 38098170
Role of Neutrophil Extracellular Traps in Health and Disease Pathophysiology: Recent Insights and Advances.
Islam MM, Takeyama N. Islam MM, et al. Int J Mol Sci. 2023 Oct 31;24(21):15805. doi: 10.3390/ijms242115805. Int J Mol Sci. 2023. PMID: 37958788 Free PMC article. Review.
Immunoaging - the effect of age on serum levels of NET biomarkers in men: a pilot study.
Garley M, Omeljaniuk WJ, Motkowski R, Ratajczak-Wrona W, Jabłońska E, Filipkowski D, Charkiewicz AE. Garley M, et al. Int J Occup Med Environ Health. 2023 Sep 7;36(3):333-348. doi: 10.13075/ijomeh.1896.02125. Epub 2023 Aug 28. Int J Occup Med Environ Health. 2023. PMID: 37681423 Free PMC article.
The effect of local anaesthetics on apoptosis and NETosis of human neutrophils in vitro: comparison between lidocaine and ropivacaine.
Kulińska KI, Szałkowska S, Andrusiewicz M, Kotwicka M, Billert H. Kulińska KI, et al. Hum Cell. 2023 Nov;36(6):2027-2039. doi: 10.1007/s13577-023-00963-x. Epub 2023 Aug 17. Hum Cell. 2023. PMID: 37589878 Free PMC article.
Mitochondrial ROS and base excision repair steps leading to DNA nick formation drive ultraviolet induced-NETosis.
Azzouz D, Palaniyar N. Azzouz D, et al. Front Immunol. 2023 Jun 7;14:1198716. doi: 10.3389/fimmu.2023.1198716. eCollection 2023. Front Immunol. 2023. PMID: 37350954 Free PMC article.

See all "Cited by" articles

References

1. Takei H, Araki A, Watanabe H, Ichinose A, Sendo F. Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis. J. Leukoc. Biol. 1996;59:229–240. doi: 10.1002/jlb.59.2.229. - DOI - PubMed
1. Brinkmann V, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–1535. doi: 10.1126/science.1092385. - DOI - PubMed
1. Douda DN, Khan MA, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc. Natl. Acad. Sci. 2015;112:2817–2822. doi: 10.1073/pnas.1414055112. - DOI - PMC - PubMed
1. Azzouz D, Khan MA, Sweezey N, Palaniyar N. Two-in-one: UV radiation simultaneously induces apoptosis and NETosis. Cell Death Discov. 2018;4:51. doi: 10.1038/s41420-018-0048-3. - DOI - PMC - PubMed
1. Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and-independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J. Biol. Chem. 1998;273:8389–8397. doi: 10.1074/jbc.273.14.8389. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

Grants and funding

MOP-111012 /CIHR/Canada

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Takei H, Araki A, Watanabe H, Ichinose A, Sendo F. Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis. J. Leukoc. Biol. 1996;59:229–240. doi: 10.1002/jlb.59.2.229. - DOI - PubMed

[2] Takei H, Araki A, Watanabe H, Ichinose A, Sendo F. Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis. J. Leukoc. Biol. 1996;59:229–240. doi: 10.1002/jlb.59.2.229. - DOI - PubMed

[3] Brinkmann V, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–1535. doi: 10.1126/science.1092385. - DOI - PubMed

[4] Brinkmann V, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–1535. doi: 10.1126/science.1092385. - DOI - PubMed

[5] Douda DN, Khan MA, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc. Natl. Acad. Sci. 2015;112:2817–2822. doi: 10.1073/pnas.1414055112. - DOI - PMC - PubMed

[6] Douda DN, Khan MA, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc. Natl. Acad. Sci. 2015;112:2817–2822. doi: 10.1073/pnas.1414055112. - DOI - PMC - PubMed

[7] Azzouz D, Khan MA, Sweezey N, Palaniyar N. Two-in-one: UV radiation simultaneously induces apoptosis and NETosis. Cell Death Discov. 2018;4:51. doi: 10.1038/s41420-018-0048-3. - DOI - PMC - PubMed

[8] Azzouz D, Khan MA, Sweezey N, Palaniyar N. Two-in-one: UV radiation simultaneously induces apoptosis and NETosis. Cell Death Discov. 2018;4:51. doi: 10.1038/s41420-018-0048-3. - DOI - PMC - PubMed

[9] Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and-independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J. Biol. Chem. 1998;273:8389–8397. doi: 10.1074/jbc.273.14.8389. - DOI - PubMed

[10] Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and-independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J. Biol. Chem. 1998;273:8389–8397. doi: 10.1074/jbc.273.14.8389. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis

Affiliations

ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources