Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians

Hum Mol Genet. 2018 Nov 15;27(22):3901-3910. doi: 10.1093/hmg/ddy285.

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are the major types of chronic inflammatory bowel disease (IBD) characterized by recurring episodes of inflammation of the gastrointestinal tract. Although it is well established that human leukocyte antigen (HLA) is a major risk factor for IBD, it is yet to be determined which HLA alleles or amino acids drive the risks of CD and UC in Asians. To define the roles of HLA for IBD in Asians, we fine-mapped HLA in 12 568 individuals from Korea and Japan (3294 patients with CD, 1522 patients with UC and 7752 controls). We identified that the amino acid position 37 of HLA-DRβ1 plays a key role in the susceptibility to CD (presence of serine being protective, P = 3.6 × 10-67, OR = 0.48 [0.45-0.52]). For UC, we confirmed the known association of the haplotype spanning HLA-C*12:02, HLA-B*52:01 and HLA-DRB1*1502 (P = 1.2 × 10-28, OR = 4.01 [3.14-5.12]).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Substitution / genetics
  • Amino Acids / chemistry
  • Amino Acids / genetics
  • Asian Continental Ancestry Group / genetics
  • Colitis, Ulcerative / genetics*
  • Colitis, Ulcerative / pathology
  • Crohn Disease / genetics*
  • Crohn Disease / pathology
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype
  • HLA-DRB1 Chains / chemistry
  • HLA-DRB1 Chains / genetics*
  • Haplotypes / genetics
  • Humans
  • Inflammatory Bowel Diseases / genetics*
  • Inflammatory Bowel Diseases / pathology
  • Japan
  • Male
  • Protein Conformation
  • Republic of Korea

Substances

  • Amino Acids
  • HLA-DRB1 Chains