Dietary total antioxidant capacity is inversely related to menopausal symptoms: a cross-sectional study among Iranian postmenopausal women

Nutrition. 2018 Nov:55-56:161-167. doi: 10.1016/j.nut.2018.04.014. Epub 2018 Jun 7.


Objective: The aim of this study was to assess the association between dietary total antioxidant capacity (DTAC) and menopausal symptoms (MS) in postmenopausal middle-aged women.

Methods: A cross-sectional study was conducted with 400 postmenopausal women who referred to municipality health houses and health centers in south Tehran, Iran. Sociodemographic data and anthropometric measures such as body weight, height, and waist circumference were determined. Dietary intake was assessed using a 147-item validated food frequency questionnaire. Energy-adjusted DTAC was calculated using the US Department of Agriculture database. Individual MS was measured by the Menopause Rating Scale questionnaire.

Results: Multivariable linear regression analyses indicated that DTAC was negatively associated with total Menopause Rating Scale score, somatic and psychological score, which was independent of confounding variables such as age, education, waist circumference, total physical activity, dietary intake of fiber, tea and coffee intake, total energy intake, and dietary supplement use (P < 0.001). Additionally, in logistic regression, a negative association between MS and DTAC was observed, which was independent of confounding variables (Ptrend = 0.002). Logistic regression for each symptom indicated that higher DTAC was associated with reduction in hot flashes and sweating, sleep problems, anxiety, exhaustion, and difficulty concentrating. However, a significant positive association was observed between DTAC and sexual problems.

Conclusion: DTAC is inversely associated with MS, which could be of particular significance for somatic and psychological symptoms. These findings indicate that DTAC could be an important basis for developing an effective dietary measure for reducing MS.

Keywords: Antioxidant; Dietary total antioxidant capacity; Hot flashes; Menopause symptoms.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anthropometry
  • Antioxidants / analysis*
  • Cross-Sectional Studies
  • Diet / statistics & numerical data*
  • Diet Surveys
  • Female
  • Hot Flashes / epidemiology
  • Hot Flashes / etiology
  • Humans
  • Iran
  • Linear Models
  • Menopause / physiology*
  • Menopause / psychology*
  • Middle Aged
  • Multivariate Analysis
  • Postmenopause


  • Antioxidants