Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature

BMC Infect Dis. 2018 Aug 7;18(1):381. doi: 10.1186/s12879-018-3284-5.


Background: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex.

Case presentation: We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient's serum.

Conclusion: Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.

Keywords: Epidemic myalgia; Human parechovirus type 3; IL-6; Orchiodynia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Child, Preschool
  • Diarrhea / blood
  • Diarrhea / complications
  • Diarrhea / virology
  • Humans
  • Interleukin-6 / blood*
  • Male
  • Nuclear Family
  • Parechovirus / genetics
  • Parechovirus / immunology
  • Parechovirus / isolation & purification*
  • Picornaviridae Infections / blood
  • Picornaviridae Infections / diagnosis*
  • Picornaviridae Infections / epidemiology
  • Pleurodynia, Epidemic / blood
  • Pleurodynia, Epidemic / diagnosis*
  • Pleurodynia, Epidemic / virology*
  • Sepsis / blood
  • Sepsis / diagnosis
  • Sepsis / epidemiology
  • Sepsis / virology


  • Interleukin-6