Proximal-type epithelioid sarcoma of the oral cavity: a case report and literature review

Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Nov;126(5):e258-e263. doi: 10.1016/j.oooo.2018.05.049. Epub 2018 Jun 21.


Proximal-type epithelioid sarcoma (PES) is an exceedingly rare malignant tumor of soft tissue; PES within the oral cavity is even rarer. Pathologic examination is the primary diagnostic modality, and surgical treatment is recommended as the preferred method for the treatment of PES. Currently, there is a paucity of literature that systematically reports on PES in the oral cavity. Here, we describe a 42-year-old man with PES in the oral cavity, which showed positivity for vimentin, cytokeratin, CD31, S-100 but did not express BCL-2, HMB-45, or desmin. We performed a wide excision and neck dissection, and then used the free anterolateral thigh flap to reconstruct the defect in the soft tissue. Furthermore, we review the current literature with regard to diagnosis and treatment of PES.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Diagnostic Imaging
  • Free Tissue Flaps / transplantation
  • Humans
  • Male
  • Mouth Neoplasms / diagnosis*
  • Mouth Neoplasms / pathology
  • Mouth Neoplasms / surgery*
  • Neck Dissection
  • Sarcoma / diagnosis*
  • Sarcoma / pathology
  • Sarcoma / surgery*
  • Soft Tissue Neoplasms / diagnosis*
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / surgery*
  • Thigh