Regulation of striatal cells and goal-directed behavior by cerebellar outputs

Nat Commun. 2018 Aug 7;9(1):3133. doi: 10.1038/s41467-018-05565-y.

Abstract

The cerebellum integrates descending motor commands and sensory information to generate predictions and detect errors during ongoing behaviors. Cerebellar computation has been proposed to control motor but also non-motor behaviors, including reward expectation and cognitive flexibility. However, the organization and functional contribution of cerebellar output channels are incompletely understood. Here, we elaborate the cell-type specificity of a broad connectivity matrix from the deep cerebellar nuclei (DCN) to the dorsal striatum in mice. Cerebello-striatal connections arise from all deep cerebellar subnuclei and are relayed through intralaminar thalamic nuclei (ILN). In the dorsal striatum, these connections target medium spiny neurons, but also ChAT-positive interneurons, a class of tonically active interneurons implicated in shifting and updating behavioral strategies. Chemogenetic silencing of cerebello-striatal connectivity modifies function of striatal ChAT-positive interneurons. We propose that cerebello-striatal connections relay cerebellar computation to striatal circuits for goal-directed behaviors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal*
  • Cerebellum / metabolism*
  • Corpus Striatum / cytology
  • Corpus Striatum / metabolism*
  • Electrophysiological Phenomena
  • Female
  • Gene Expression Regulation*
  • Gene Silencing
  • Humans
  • Interneurons / metabolism*
  • Male
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Motivation
  • Neurons / metabolism
  • Phenotype
  • Synapsins / genetics

Substances

  • Synapsins