Protective effects of α-bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol-induced myocardial infarction: In vivo and in vitro evidences

J Biochem Mol Toxicol. 2018 Oct;32(10):e22200. doi: 10.1002/jbt.22200. Epub 2018 Aug 8.

Abstract

The effect of α-bisabolol on hemodyanimcs, lipid peroxidation, and nonenzymatic antioxidants was evaluated in isoproterenol-induced myocardial infarction in rats. They were pre- and cotreated with α-bisabolol (25 mg/kg body weight) daily for 10 days along with the subcutaneous injection of isoproterenol (85 mg/kg body weight) at an interval of 24 hours for 2 days (9th and 10th days). Increased activities of serum creatine kinase and creatine kinase-MB along with altered levels/concentrations of lipid peroxidation products and nonenzymatic status were observed in the plasma and heart tissues of rats. Treatment with α-bisabolol showed protective effects by reversing the altered biochemical parameters and hemodynamics studied. The in vitro reducing power of α-bisabolol confirmed its potent antioxidant action. These biochemical benefits were translated into functional recovery by the maintenance of the hemodynamics in rats. The findings showed that α-bisabolol has the potential to protect against isoproterenol-induced myocardial infarction due to its potent antilipid peroxidation and antioxidant properties.

Keywords: antioxidants; hemodynamics alterations; isoproterenol; lipid peroxidation; myocardial infarction; α-bisabolol.

MeSH terms

  • Adrenergic beta-Agonists / toxicity*
  • Animals
  • Antioxidants / metabolism*
  • Creatine Kinase / blood
  • Creatine Kinase, MB Form / blood
  • Hemodynamics / drug effects*
  • In Vitro Techniques
  • Isoproterenol / toxicity*
  • Lipid Peroxidation / drug effects*
  • Male
  • Monocyclic Sesquiterpenes
  • Myocardial Infarction / chemically induced
  • Myocardial Infarction / metabolism*
  • Myocardial Infarction / physiopathology
  • Oxidative Stress / drug effects
  • Rats, Wistar
  • Sesquiterpenes / pharmacology*

Substances

  • Adrenergic beta-Agonists
  • Antioxidants
  • Monocyclic Sesquiterpenes
  • Sesquiterpenes
  • bisabolol
  • Creatine Kinase
  • Creatine Kinase, MB Form
  • Isoproterenol