Regional brain homovanillic acid following delta 9-tetrahydrocannabinol and cocaine

Brain Res. 1986 Feb 26;366(1-2):405-7. doi: 10.1016/0006-8993(86)91329-6.

Abstract

delta 9-Tetrahydrocannabinol (10 mg/kg) increased homovanillic acid in rat prefrontal cortex and olfactory tubercle. This dose did not affect homovanillic acid in the caudate. Higher doses increased homovanillic acid in all 3 regions. Cocaine (20, 30, or 50 mg/kg) did not affect homovanillic acid in any of these brain regions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects*
  • Caudate Nucleus / analysis
  • Cocaine / pharmacology*
  • Dronabinol / pharmacology*
  • Frontal Lobe / analysis
  • Homovanillic Acid / analysis*
  • Male
  • Olfactory Bulb / analysis
  • Rats
  • Rats, Inbred Strains

Substances

  • Dronabinol
  • Cocaine
  • Homovanillic Acid