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, 32 (4), 290-295

Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes With Behçet Disease Without Active Inflammation

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Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes With Behçet Disease Without Active Inflammation

Yoo Ri Chung et al. Korean J Ophthalmol.

Abstract

Purpose: To investigate whether subfoveal choroidal thickness, measured using enhanced depth imaging optical coherence tomography (EDI-OCT), is an indicator of subclinical ocular or systemic inflammation in eyes with Behçet disease (BD) without active ocular inflammation.

Methods: A retrospective analysis was used to examine clinical features of non-uveitic patients with BD (NUBD group), patients with a previous history of Behçet uveitis in an inactive state (IUBD group), and healthy controls were evaluated from October 2014 to September 2015. Subfoveal choroidal thickness was measured using EDI-OCT.

Results: The NUBD group included 46 eyes in 24 patients; the IUBD group included 16 eyes in 11 patients; and the control group included 35 eyes in 23 individuals. The mean subfoveal choroidal thicknesses differed significantly among these groups. Choroidal thickness was significantly greater in the NUBD (310.5 ± 81.0 μm) than in the IUBD (263.1 ± 56.6 μm, p = 0.013) and control (256.9 ± 67.9 μm, p = 0.002) groups. The disease activity score was significantly higher in the NUBD than in the IUBD group (p < 0.001), while the use of cyclosporine was significantly associated with choroidal thickness in eyes with NUBD (p = 0.039).

Conclusions: Subfoveal choroidal thickness, as measured by EDI-OCT, may be a clinical indicator of subclinical ocular inflammation and systemic inflammation in BD patients without active ocular inflammation.

Keywords: Behcet syndrome; Choroidal thickness; Inflammation.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Subfoveal choroidal thicknesses in the three groups of eyes. Mean choroidal thickness was significantly greater in the non-uveitic Behçet disease (NUBD) than in the inactive uveitic Behçet disease (IUBD) and control groups.

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