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, 32 (4), 290-295

Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes With Behçet Disease Without Active Inflammation


Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes With Behçet Disease Without Active Inflammation

Yoo Ri Chung et al. Korean J Ophthalmol.


Purpose: To investigate whether subfoveal choroidal thickness, measured using enhanced depth imaging optical coherence tomography (EDI-OCT), is an indicator of subclinical ocular or systemic inflammation in eyes with Behçet disease (BD) without active ocular inflammation.

Methods: A retrospective analysis was used to examine clinical features of non-uveitic patients with BD (NUBD group), patients with a previous history of Behçet uveitis in an inactive state (IUBD group), and healthy controls were evaluated from October 2014 to September 2015. Subfoveal choroidal thickness was measured using EDI-OCT.

Results: The NUBD group included 46 eyes in 24 patients; the IUBD group included 16 eyes in 11 patients; and the control group included 35 eyes in 23 individuals. The mean subfoveal choroidal thicknesses differed significantly among these groups. Choroidal thickness was significantly greater in the NUBD (310.5 ± 81.0 μm) than in the IUBD (263.1 ± 56.6 μm, p = 0.013) and control (256.9 ± 67.9 μm, p = 0.002) groups. The disease activity score was significantly higher in the NUBD than in the IUBD group (p < 0.001), while the use of cyclosporine was significantly associated with choroidal thickness in eyes with NUBD (p = 0.039).

Conclusions: Subfoveal choroidal thickness, as measured by EDI-OCT, may be a clinical indicator of subclinical ocular inflammation and systemic inflammation in BD patients without active ocular inflammation.

Keywords: Behcet syndrome; Choroidal thickness; Inflammation.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.


Fig. 1
Fig. 1. Subfoveal choroidal thicknesses in the three groups of eyes. Mean choroidal thickness was significantly greater in the non-uveitic Behçet disease (NUBD) than in the inactive uveitic Behçet disease (IUBD) and control groups.

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