Photoinduced Deaminative Borylation of Alkylamines

J Am Chem Soc. 2018 Aug 29;140(34):10700-10704. doi: 10.1021/jacs.8b07103. Epub 2018 Aug 21.


An operationally simple deaminative borylation reaction of primary alkylamines has been developed. The formation of electron-donor-acceptor complexes between N-alkylpyridinium salts and bis(catecholato)diboron enables photoinduced single-electron transfer and fragmentation to carbon-centered radicals, which are subsequently borylated. The mild conditions allow a diverse range of readily available alkylamines to be efficiently converted into synthetically valuable alkylboronic esters under catalyst-free conditions.

Publication types

  • Research Support, Non-U.S. Gov't