Small RNAs, but Sizable Itch: TRPA1 Activation by an Extracellular MicroRNA

Tayler D Sheahan; Junichi Hachisuka; Sarah E Ross

doi:10.1016/j.neuron.2018.07.040

Small RNAs, but Sizable Itch: TRPA1 Activation by an Extracellular MicroRNA

Neuron. 2018 Aug 8;99(3):421-422. doi: 10.1016/j.neuron.2018.07.040.

Authors

Tayler D Sheahan¹, Junichi Hachisuka¹, Sarah E Ross²

Affiliations

¹ Department of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
² Department of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: saross@pitt.edu.

PMID: 30092208
DOI: 10.1016/j.neuron.2018.07.040

Abstract

Chronic itch is a major symptom of cutaneous T cell lymphoma (CTCL). In this issue of Neuron, Han and colleagues (2018) provide evidence that one of the itch mediators in CTCL is an extracellular miRNA that directly activates TRPA1 on sensory neurons.

Publication types

Comment

MeSH terms

Humans
MicroRNAs*
Pruritus
Sensory Receptor Cells
TRPA1 Cation Channel
Transient Receptor Potential Channels*

Substances

MicroRNAs
TRPA1 Cation Channel
TRPA1 protein, human
Transient Receptor Potential Channels

Grants and funding

R01 AR063772/AR/NIAMS NIH HHS/United States