The CeNGEN Project: The Complete Gene Expression Map of an Entire Nervous System

Marc Hammarlund; Oliver Hobert; David M Miller 3rd; Nenad Sestan

doi:10.1016/j.neuron.2018.07.042

The CeNGEN Project: The Complete Gene Expression Map of an Entire Nervous System

Neuron. 2018 Aug 8;99(3):430-433. doi: 10.1016/j.neuron.2018.07.042.

Authors

Marc Hammarlund¹, Oliver Hobert², David M Miller 3rd³, Nenad Sestan⁴

Affiliations

¹ Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA. Electronic address: marc.hammarlund@yale.edu.
² Department of Biological Sciences, Columbia University, New York, New York, USA; Howard Hughes Medical Institute.
³ Department of Cell and Developmental Biology and Program in Neuroscience, Vanderbilt University, Nashville, TN, USA.
⁴ Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.

Abstract

Differential gene expression defines individual neuron types and determines how each contributes to circuit physiology and responds to injury and disease. The C. elegans Neuronal Gene Expression Map & Network (CeNGEN) will establish a comprehensive gene expression atlas of an entire nervous system at single-neuron resolution.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins / genetics*
Chromosome Mapping / methods
Chromosome Mapping / trends*
Gene Expression Profiling / methods
Gene Expression Profiling / trends
National Institute of Neurological Disorders and Stroke (U.S.) / trends*
Nervous System
Nervous System Physiological Phenomena / genetics*
United States

Substances

Caenorhabditis elegans Proteins

Grants and funding

R01 NS100547/NS/NINDS NIH HHS/United States