Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life

Mol Nutr Food Res. 2018 Nov;62(21):e1800463. doi: 10.1002/mnfr.201800463. Epub 2018 Aug 24.

Abstract

Scope: Resveratrol (RSV) and nicotinamide riboside (NR) are food compounds with anti-obesity actions in adult rodents. Here, the long-term effects of RSV and NR mild supplementation throughout lactation on adiposity-related parameters and the appearance of the beige phenotype in white adipose tissue (WAT) in adulthood are assessed.

Methods and results: Newborn mice received orally RSV or NR from day 2 to 20 of life. Control littermates received the vehicle. All animals are weaned onto a chow diet on day 21. On day 90, half the animals of each group are assigned to a high-fat diet (HFD) for 10 weeks, while the other remained on a normal-fat diet. Energy-balance-related parameters, blood parameters, and gene expression and immunohistochemical analysis of WAT are assessed. Treated male mice show an improved response to the HFD, such as delayed body weight gain, a blunted increase in the plasma leptin/adiponectin ratio, and a decreased lipolytic response, together with signs of white-to-brown fat remodeling in inguinal WAT. These effects are absent in female mice.

Conclusion: RSV and NR supplementations in early postnatal life affect WAT's thermogenic/oxidative transcriptional phenotype and metabolic responses in adulthood, with upregulatory and beneficial effects evidenced in male animals.

Keywords: adipose tissue; metabolic programming; nicotinamide riboside; resveratrol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, Brown / drug effects
  • Adipose Tissue, Brown / physiology
  • Adipose Tissue, White / drug effects*
  • Adipose Tissue, White / physiology
  • Age Factors
  • Animals
  • Animals, Newborn
  • Body Weight / drug effects
  • Diet, High-Fat / adverse effects*
  • Dietary Supplements
  • Female
  • Gene Expression Regulation / drug effects
  • Lactation
  • Male
  • Mice, Inbred Strains
  • Niacinamide / analogs & derivatives*
  • Niacinamide / pharmacology
  • Phenotype
  • Resveratrol / pharmacology*
  • Thermogenesis / drug effects
  • Thermogenesis / genetics

Substances

  • nicotinamide-beta-riboside
  • Niacinamide
  • Resveratrol