Evaluation of antibodies to Epstein-Barr virus in Italian patients with nasopharyngeal carcinoma

J Infect. 1986 Mar;12(2):127-31. doi: 10.1016/s0163-4453(86)93558-9.


An association of Epstein-Barr virus (EBV) with nasopharyngeal carcinoma (NPC) has been established serologically in Italian patients. The finding of IgA antibodies to EBV-capsid antigen (VCA) and to early antigen (EA) showed a high degree of correlation for patients with NPC, thereby confirming previous reports. In addition, when considered together, IgA anti-VCA and IgG anti-EA antibody titres appeared to distinguish NPC-patients from those in control populations. Poorly differentiated and undifferentiated carcinomas with lymphoid cellular infiltrations showed the highest frequency of association with positive EBV serological tests.

MeSH terms

  • Antibodies, Viral / analysis*
  • Antigens, Viral / immunology
  • Capsid Proteins*
  • Carcinoma / immunology*
  • Carcinoma / microbiology
  • Carcinoma, Squamous Cell / immunology*
  • Carcinoma, Squamous Cell / microbiology
  • Epstein-Barr Virus Nuclear Antigens
  • Fluorescent Antibody Technique
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Immunoglobulin A / analysis
  • Immunoglobulin A / immunology
  • Immunoglobulin G / analysis
  • Immunoglobulin G / immunology
  • Italy
  • Lymphatic Metastasis
  • Nasopharyngeal Neoplasms / immunology*
  • Nasopharyngeal Neoplasms / microbiology


  • Antibodies, Viral
  • Antigens, Viral
  • Capsid Proteins
  • Epstein-Barr Virus Nuclear Antigens
  • Epstein-Barr viral capsid antigen
  • Epstein-Barr virus early antigen
  • Immunoglobulin A
  • Immunoglobulin G