Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome - A prospective observational study

Eur J Obstet Gynecol Reprod Biol. 2018 Oct;229:15-19. doi: 10.1016/j.ejogrb.2018.08.001. Epub 2018 Aug 2.

Abstract

Objective: The main purpose of this study was to determine the prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome (PCOS) and to explore the association of hypovitaminosis D with metabolic syndrome in women with PCOS.

Study design: A prospective observational study was conducted in a tertiary care, infertility centre from March 2016 to March 2017. The primary outcome was estimation of the prevalence of vitamin D deficiency in infertile PCOS women. Secondary outcomes were to study the association of hypovitaminosis D with metabolic syndrome, obesity and hypercholesterolemia in PCOS patients.

Results: A total of 256 infertile women with PCOS were included in the study. Vitamin D deficiency was observed in 70.3% women, 20.3% were vitamin D insufficient and only 9.4% were vitamin D sufficient. Metabolic syndrome was seen in 80/256 (31.25%) women. There was no evidence of an association between hypovitaminosis D and metabolic syndrome, obesity or hyperlipidemia. There was a strong evidence of an association between waist circumference of >80 cm and vitamin D deficiency (p = 0.02).

Conclusion: Vitamin D deficiency is highly prevalent in infertile PCOS women and there seems to be no association between hypovitaminosis D and the metabolic syndrome in the same population.

Keywords: Hypovitaminosis D; Polycystic ovarian syndrome; Vitamin D.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Female
  • Humans
  • India / epidemiology
  • Infertility, Female / etiology
  • Metabolic Syndrome / complications
  • Metabolic Syndrome / epidemiology*
  • Polycystic Ovary Syndrome / complications
  • Polycystic Ovary Syndrome / epidemiology*
  • Prevalence
  • Prospective Studies
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / epidemiology*
  • Young Adult