Fluorescence-guided surgery for liver tumors

J Surg Oncol. 2018 Aug;118(2):324-331. doi: 10.1002/jso.25128. Epub 2018 Aug 11.


In hepatobiliary surgery, fluorescence imaging enables identification of subcapsular liver tumors through accumulation of indocyanine green after preoperative intravenous injection in cancerous tissues of hepatocellular carcinoma and in noncancerous hepatic parenchyma around intrahepatic cholangiocarcinoma and liver metastases. Indocyanine green-fluorescence imaging can also be used for visualizing extrahepatic bile duct anatomy and hepatic segmental boundaries, enhancing the accuracy of open and laparoscopic hepatectomy.

Keywords: colorectal liver metastasis (CRLM); fluorescence imaging; hepatocellular carcinoma (HCC); indocyanine green (ICG); liver resection.

Publication types

  • Review

MeSH terms

  • Carcinoma, Hepatocellular / diagnostic imaging
  • Carcinoma, Hepatocellular / surgery
  • Coloring Agents
  • Humans
  • Indocyanine Green
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / surgery*
  • Optical Imaging / methods*
  • Surgery, Computer-Assisted / methods*


  • Coloring Agents
  • Indocyanine Green