Gastrinomas: Medical or Surgical Treatment

Endocrinol Metab Clin North Am. 2018 Sep;47(3):577-601. doi: 10.1016/j.ecl.2018.04.009.


This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma). It concentrates on the status at present but also briefly reviews the changes over time in treatment approaches. Generally, surgical and medical therapy are complementary today; however, in some cases, such as patients with ZES and multiple endocrine neoplasia type 1, the treatment approach remains controversial.

Keywords: Acid secretion; Gastrinoma; Multiple endocrine neoplasia type 1; Neuroendocrine tumor; Proton pump inhibitors; Zollinger-Ellison syndrome.

Publication types

  • Review

MeSH terms

  • Gastrinoma / drug therapy*
  • Gastrinoma / surgery*
  • Humans
  • Multiple Endocrine Neoplasia Type 1 / drug therapy
  • Multiple Endocrine Neoplasia Type 1 / surgery
  • Neuroendocrine Tumors / drug therapy*
  • Neuroendocrine Tumors / surgery*
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / surgery*
  • Zollinger-Ellison Syndrome / drug therapy*
  • Zollinger-Ellison Syndrome / surgery*