This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma). It concentrates on the status at present but also briefly reviews the changes over time in treatment approaches. Generally, surgical and medical therapy are complementary today; however, in some cases, such as patients with ZES and multiple endocrine neoplasia type 1, the treatment approach remains controversial.
Keywords: Acid secretion; Gastrinoma; Multiple endocrine neoplasia type 1; Neuroendocrine tumor; Proton pump inhibitors; Zollinger-Ellison syndrome.
Published by Elsevier Inc.