Directional brain networks underlying OM chanting

Asian J Psychiatr. 2018 Oct;37:20-25. doi: 10.1016/j.ajp.2018.08.001. Epub 2018 Aug 3.

Abstract

OM chanting is an ancient technique of Indian meditation. OM chanting is associated with an experience of relaxation, changes in autonomic balance and deactivation of limbic brain regions. While functional localization is important, how brain regions interact with each other has been shown to underlie various brain functions. Therefore, in this study, we tested the hypothesis that there is reduced communication between deactivated regions during OM chanting. In order to do so, we employed multivariate autoregressive model (MVAR) based Granger causality to obtain directional connectivity between deactivated regions. fMRI scans of 12 right handed healthy volunteers (9 Men) from a previously published study was used in which participants performed OM chanting and a control condition in a block design. We found that outputs from insula, anterior cingulate and orbitofrontal cortices were significantly reduced in OM condition. Of interest is the reduction of outputs from these regions to limbic area amygdala. Modulation of brain regions involved in emotion processing and implicated in major depressive disorder (MDD) raises a potential possibility of OM chanting in the treatment of MDD.

Keywords: Connectivity; Directional connectivity; Functional MRI; Granger causality; Meditation; OM chanting; fMRI.

MeSH terms

  • Adult
  • Amygdala / diagnostic imaging
  • Amygdala / physiology*
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / physiology*
  • Connectome / methods*
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Meditation*
  • Nerve Net / diagnostic imaging
  • Nerve Net / physiology*
  • Young Adult