FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area

Dev Cell. 2018 Sep 10;46(5):564-580.e5. doi: 10.1016/j.devcel.2018.07.010. Epub 2018 Aug 9.


The olfactory epithelium (OE) is a neurosensory organ required for the sense of smell. Turbinates, bony projections from the nasal cavity wall, increase the surface area within the nasal cavity lined by the OE. Here, we use engineered fibroblast growth factor 20 (Fgf20) knockin alleles to identify a population of OE progenitor cells that expand horizontally during development to populate all lineages of the mature OE. We show that these Fgf20-positive epithelium-spanning progenitor (FEP) cells are responsive to Wnt/β-Catenin signaling. Wnt signaling suppresses FEP cell differentiation into OE basal progenitors and their progeny and positively regulates Fgf20 expression. We further show that FGF20 signals to the underlying mesenchyme to regulate the growth of turbinates. These studies thus identify a population of OE progenitor cells that function to scale OE surface area with the underlying turbinates.

Keywords: FGF20; Wnt/β-Catenin; condensation; olfactory epithelium; progenitor cell; tissue scaling; turbinate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cells, Cultured
  • Female
  • Fibroblast Growth Factors / physiology*
  • Male
  • Mesoderm / cytology*
  • Mesoderm / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Olfactory Mucosa / cytology
  • Olfactory Mucosa / embryology
  • Olfactory Mucosa / physiology*
  • Stem Cells / cytology
  • Stem Cells / physiology*
  • Turbinates / growth & development*
  • Wnt Signaling Pathway*


  • Fgf20 protein, mouse
  • Fibroblast Growth Factors