Cachectin and tumour necrosis factor as two sides of the same biological coin

Nature. 1986 Apr 17-23;320(6063):584-8. doi: 10.1038/320584a0.

Abstract

In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antineoplastic Agents
  • Biological Evolution
  • Cachexia / physiopathology*
  • Endotoxins / pharmacology
  • Genes
  • Glycoproteins / physiology*
  • Glycoproteins / therapeutic use
  • Humans
  • Lipoprotein Lipase / antagonists & inhibitors*
  • Lymphotoxin-alpha / genetics
  • Proteins / physiology*
  • Proteins / therapeutic use
  • Receptors, Cell Surface / physiology
  • Receptors, Tumor Necrosis Factor
  • Sequence Homology, Nucleic Acid
  • Tumor Necrosis Factor-alpha

Substances

  • Antineoplastic Agents
  • Endotoxins
  • Glycoproteins
  • Lymphotoxin-alpha
  • Proteins
  • Receptors, Cell Surface
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha
  • Lipoprotein Lipase