Is Severe and Long-lasting Linezolid-induced Optic Neuropathy Reversible?

Intern Med. 2018 Dec 15;57(24):3611-3613. doi: 10.2169/internalmedicine.1344-18. Epub 2018 Aug 10.


Linezolid is a useful drug for treating drug-resistant tuberculosis. However, the associated toxicities, especially optic neuritis, are a major obstacle for its long-term use. We recently experienced a case of severe optic and peripheral neuropathy during the treatment of multidrug-resistant tuberculosis. The treatment continued for 12 months despite severe optic and peripheral neuropathy. At eight months after the discontinuation of the drug, the optic neuropathy recovered, but the peripheral neuropathy did not. Considering the grave prognosis of drug-resistant tuberculosis, the continuation of linezolid despite neurotoxicity under close observation may be a suitable option.

Keywords: MDR-TB; linezolid; neuropathy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antitubercular Agents / adverse effects*
  • Female
  • Humans
  • Linezolid / adverse effects*
  • Optic Nerve Diseases / chemically induced*
  • Peripheral Nervous System Diseases / chemically induced
  • Prognosis
  • Treatment Outcome
  • Tuberculosis, Multidrug-Resistant / drug therapy*
  • Withholding Treatment


  • Antitubercular Agents
  • Linezolid