Acetylcholine receptors and acetylcholinesterase activity in soleus muscle of trembler dysmyelinating mutant: a cytochemical and biochemical analysis

Neurosci Lett. 1986 Mar 28;65(1):72-8. doi: 10.1016/0304-3940(86)90122-9.

Abstract

We performed comparative biochemical and morphological studies of trembler and control soleus muscles. In the mutant, small multiple endplates were observed on some muscle fibers. The acetylcholine receptor (AChR) concentration and the acetylcholinesterase (AChE) activity of the muscle were not modified in the mutant. Our results suggest that both AChR and AChE levels are similar in trembler and control soleus but that these molecules are localized differently in the sarcolemma of the mutant muscles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Animals
  • Autoradiography
  • Mice
  • Mice, Neurologic Mutants
  • Motor Endplate / metabolism*
  • Muscles / metabolism*
  • Myelin Sheath*
  • Neuromuscular Junction / metabolism*
  • Peripheral Nervous System Diseases / metabolism*
  • Receptors, Cholinergic / analysis
  • Receptors, Cholinergic / metabolism*

Substances

  • Receptors, Cholinergic
  • Acetylcholinesterase