Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 11 (9), 889-902

Efficacy, Tolerability, and Safety of Serotonergic Psychedelics for the Management of Mood, Anxiety, and Substance-Use Disorders: A Systematic Review of Systematic Reviews

Affiliations
Review

Efficacy, Tolerability, and Safety of Serotonergic Psychedelics for the Management of Mood, Anxiety, and Substance-Use Disorders: A Systematic Review of Systematic Reviews

Rafael G Dos Santos et al. Expert Rev Clin Pharmacol.

Abstract

Mood, anxiety, and substance-use disorders are among the most prevalent psychiatric disorders in the population. Although several pharmacological treatments are available, they are not effective for a significant proportion of patients and are associated with several adverse reactions. Therefore, new treatments should be explored. Recent studies suggest that serotonergic hallucinogens/psychedelics including ayahuasca, psilocybin, and lysergic acid diethylamide (LSD) have anxiolytic, antidepressive, and antiaddictive effects. Areas Covered: A systematic review of systematic reviews assessing the efficacy, safety, and tolerability of serotonergic hallucinogens/psychedelic was performed using the PubMed data base until 11 April 2018. Systematic reviews with or without meta-analysis were analyzed, but only reviews that described at least one randomized controlled trial (RCT) were included. Expert Commentary: Psilocybin and LSD reduced anxiety and depression in cancer patients and symptoms of alcohol and tobacco dependence, and ayahuasca reduced depression symptoms in treatment-resistant depression. Although the results are promising, several studies were open label, and only few were RCTs, and most had small sample sizes and a short duration. Single or few doses of these drugs seem to be well tolerated, but long-term studies are lacking. New RCTs with bigger samples and longer duration are needed to replicate these findings.

Keywords: 5-HT2A receptor; anxiety disorders; ayahuasca; dimethyltryptamine; lysergic acid diethylamide; mood disorders; psilocybin; substance-use disorders.

Similar articles

See all similar articles

Cited by 5 articles

MeSH terms

LinkOut - more resources

Feedback