A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti-Hepatitis C Virus-Seronegative State in a High-Risk Exposed Cohort

J Infect Dis. 2018 Nov 5;218(12):2016-2019. doi: 10.1093/infdis/jiy492.

Abstract

In this study, we examined the impact of the rs9264942 single-nucleotide polymorphism, previously shown to be associated with human immunodeficiency virus infection status and HLA-C expression, on the hepatitis C virus status in 359 people who inject drugs (PWID). The linkage of rs9264942 alleles to HLA-C antigens assigned to different expression levels was confirmed. Multivariate analysis revealed the age (P = .003) and the rs9264942 genotype (P = .006) to be independent factors for the classification to the PWID groups. Our study showed that the presence of the rs9264942 C/C genotype was associated with persistent seronegativity.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / blood*
  • Cohort Studies
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • HLA-C Antigens / genetics*
  • Hepacivirus / genetics
  • Hepatitis C / etiology
  • Hepatitis C / genetics*
  • Hepatitis C / immunology
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • RNA, Viral / isolation & purification
  • Risk Factors
  • Substance Abuse, Intravenous / complications
  • Young Adult

Substances

  • Antibodies, Viral
  • HLA-C Antigens
  • RNA, Viral