Phenytoin induced dystonia

Turk J Pediatr. 2018;60(1):111-112. doi: 10.24953/turkjped.2018.01.019.


Acar T, Alkan G, Çaksen H, Ertekin B, Ergin M, Koçak S, Cander B. Phenytoin induced dystonia. Turk J Pediatr 2018; 60: 111-112. The abnormalities of dopaminergic activity in the basal ganglia have been emphasized to be effective in dystonia. We hereby report a case of a 2.5-year-old male patient who presented with tonic-clonic sezures and who developed dystonia after being given phenytoin. Biperidene hydrochloride was administered intramuscularly; primidone was added to the treatment regimen. After a 7-day-follow-up at the hospital, the patient had no dystonia and was discharged.

Keywords: dystonia; epilepsy; phenytoin.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Child, Preschool
  • Dystonia / chemically induced*
  • Epilepsy / drug therapy*
  • Humans
  • Male
  • Phenytoin / adverse effects*
  • Primidone / therapeutic use


  • Anticonvulsants
  • Primidone
  • Phenytoin