Platelet-Rich Plasma Augments Subcision in Atrophic Acne Scars: A Split-Face Comparative Study

Dermatol Surg. 2019 Jan;45(1):90-98. doi: 10.1097/DSS.0000000000001614.


Background: Acne has a prevalence of 90% among adolescents. Facial scarring affects 75% of patients. Autologous platelet-rich plasma (PRP) is a novel treatment option for acne scar management and can be used as an adjuvant to acne scar revision procedures. Owing to its remodeling properties, PRP when used as an adjuvant reduces the total number of sittings.

Objective: To compare efficacy of autologous PRP and subcision against subcision alone in acne scars.

Methodology: It was an experimental analytical study conducted over a period of 2 years. Forty patients successfully completed the trial. It was a split-face study in which the right side of the face was the study side where autologous PRP was injected into each scar after performing subcision. The left side of the face was the control side where only subcision was performed. Digital photographs were taken at every sitting. Analysis was performed using the Wilcoxon signed-rank test and Mann-Whitney tests in SPSS software.

Results: Platelet-rich plasma and subcision showed greater improvement (32.08%) in postacne scars as compared to subcision alone (8.33%). Rolling acne scars responded greatest (39.27%) followed by box-type scars (33.88%).

Conclusion: Platelet-rich plasma and subcision act synergistically to improve the appearance of acne scars.

Publication types

  • Comparative Study

MeSH terms

  • Acne Vulgaris / complications
  • Adult
  • Atrophy
  • Cicatrix / etiology
  • Cicatrix / pathology*
  • Cicatrix / surgery
  • Cicatrix / therapy*
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Platelet-Rich Plasma*
  • Severity of Illness Index
  • Skin / pathology*
  • Time Factors
  • Treatment Outcome