Disseminated Immune Deposits in Lupus Erythematosus

Arthritis Rheum. 1977 May;20(4):962-8. doi: 10.1002/art.1780200408.

Abstract

Immunohistologic studies were performed on autopsy tissues of 2 patients with systemic lupus erythematosus. All tissues examined--the kidney, lung, spleen, liver, intestine, peritoneum, and choroid plexus--contained immune deposits. Antinuclear antibody concentration in immunoglobulin G eluted from lung and spleen tissue was higher than in serum immunoglobulin G. These findings support the assumption that in systemic lupus erythematosus the renal as well as the extrarenal lesions can be attributed to vascular deposition of immune complexes.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antinuclear / isolation & purification
  • Antigen-Antibody Complex*
  • Autopsy
  • Choroid Plexus / immunology
  • Colon / immunology
  • Complement C3
  • Female
  • Humans
  • Ileum / immunology
  • Immunoglobulin G / analysis
  • Kidney / immunology
  • Liver / immunology
  • Lung / immunology
  • Lupus Erythematosus, Systemic / immunology*
  • Microscopy, Electron
  • Microscopy, Fluorescence
  • Peritoneum / immunology
  • Spleen / immunology

Substances

  • Antibodies, Antinuclear
  • Antigen-Antibody Complex
  • Complement C3
  • Immunoglobulin G