Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression

Science. 1986 May 16;232(4752):877-80. doi: 10.1126/science.3010456.


The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Deltaretrovirus / genetics*
  • Gene Expression Regulation
  • Genes, Viral*
  • Humans
  • Interleukin-2 / biosynthesis
  • Interleukin-2 / genetics*
  • Leukemia / microbiology
  • Nucleic Acid Hybridization
  • RNA, Messenger / genetics
  • Receptors, Immunologic / genetics*
  • Receptors, Interleukin-2


  • Interleukin-2
  • RNA, Messenger
  • Receptors, Immunologic
  • Receptors, Interleukin-2