Sterol content and polyene antibiotic resistance in isolates of Candida krusei, Candida parakrusei, and Candida tropicalis

Can J Microbiol. 1977 Apr;23(4):398-401. doi: 10.1139/m77-058.

Abstract

Three isolates, one from each species of Candida krusei, C. parakrusei, and C. tropicalis, obtained from infected patients, were more tolerant of significantly higher concentrations of polyene antibiotics than the corresponding reference wild types. The resistant strains isolated had the same sterols as their wild-type counterparts but in lower concentrations.

MeSH terms

  • Amphotericin B / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Candicidin / pharmacology
  • Candida / analysis*
  • Candida / drug effects
  • Drug Resistance, Microbial
  • Ergosterol / analysis
  • Natamycin / pharmacology
  • Nystatin / pharmacology
  • Polyenes / pharmacology*
  • Species Specificity
  • Sterols / analysis*

Substances

  • Anti-Bacterial Agents
  • Polyenes
  • Sterols
  • Nystatin
  • Candicidin
  • Amphotericin B
  • Natamycin
  • Ergosterol