Identification of Missing Proteins in Normal Human Cerebrospinal Fluid

J Proteome Res. 2018 Dec 7;17(12):4315-4319. doi: 10.1021/acs.jproteome.8b00194. Epub 2018 Aug 17.

Abstract

The cerebrospinal fluid (CSF) proteome data set presented herein was obtained after immunodepletion of abundant proteins and off-gel electrophoresis fractionation of a commercial pool of normal human CSF; liquid chromatography tandem mass spectrometry analysis was performed with a linear ion trap-Orbitrap Elite. We report the identification of 12 344 peptides mapping on 2281 proteins. In the context of the Chromosome-centric Human Proteome Project (C-HPP), the existence of seven missing proteins is proposed to be validated. This data set is available to the ProteomeXchange Consortium ( http://www.proteomexchange.org/ ) with the data set identifier PXD008029.

MeSH terms

  • Cerebrospinal Fluid Proteins / analysis*
  • Cerebrospinal Fluid Proteins / isolation & purification
  • Chromatography, Liquid
  • Chromosome Mapping
  • Chromosomes, Human
  • Humans
  • Proteome / analysis*
  • Tandem Mass Spectrometry

Substances

  • Cerebrospinal Fluid Proteins
  • Proteome