Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship With High-Dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy

Sex Transm Dis. 2019 Jan;46(1):e1-e2. doi: 10.1097/OLQ.0000000000000903.

Abstract

Metronidazole-resistant trichomoniasis is an uncommon condition that presents significant therapeutic challenges. Combination therapy with high-dose oral tinidazole and vaginal paromomycin cream has been uniformly successful. We present a case report of a patient who responded to combination therapy with high-dose oral tinidazole and intravaginal paromomycin.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravaginal
  • Administration, Oral
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Humans
  • Metronidazole / therapeutic use*
  • Middle Aged
  • Paromomycin / therapeutic use
  • Tinidazole / therapeutic use*
  • Treatment Outcome
  • Trichomonas Vaginitis / diagnosis
  • Trichomonas Vaginitis / drug therapy*
  • Trichomonas vaginalis / drug effects*
  • Vagina / parasitology

Substances

  • Tinidazole
  • Metronidazole
  • Paromomycin