Transurethral thulium laser enucleation versus resection of the prostate for treating benign prostatic hyperplasia: a retrospective study

Lasers Med Sci. 2019 Mar;34(2):329-334. doi: 10.1007/s10103-018-2597-3. Epub 2018 Aug 14.


This study aimed to compare the clinical outcomes between transurethral thulium laser enucleation of the prostate (ThuLEP) and transurethral thulium laser resection of the prostate (ThuLRP) for treating benign prostatic hyperplasia (BPH). From May 2014 to August 2015, 212 patients underwent ThuLRP and 188 patients underwent ThuLEP. The ThuLEP group was further divided into two subgroups according to the ways the prostate was taken out. The perioperative parameters were recorded and analyzed. The international prostate symptom score (IPSS), quality-of-life (QoL) score, maximum flow rate (Qmax), and postvoid residual urine volume (PVR) in both groups were estimated and compared 3, 6, and 12 months after surgery. No significant difference was observed between the groups in terms of irrigated time, irrigated volume, catheterization time, and hospital stay. However, the significantly lower hemoglobin drop was observed in the ThuLRP group compared with the ThuLEP group. The ThuLEP group with a morcellator required a shorter operation time for patients with large prostate volume (> 60 mL) compared with the ThuLRP and ThuLEP groups without a morcellator. During 12 months of follow-up, IPSS, Qmax, QoL, and PVR improved significantly without significant differences between the groups. No severe complications were reported; however, the occurrence of transient urge incontinence was higher after ThuLEP compared with ThuLRP, and the proportion of urinary tract infection after surgery was higher in ThuLRP than in ThuLEP. ThuLRP and ThuLEP are safe and efficient for treating patients with symptomatic BPH. ThuLRP offers advantages in terms of minimal blood loss.

Keywords: Benign prostatic hyperplasia; Laser surgery; ThuLEP; ThuLRP; Thulium:YAG.

MeSH terms

  • Humans
  • Laser Therapy* / adverse effects
  • Length of Stay
  • Light
  • Male
  • Middle Aged
  • Operative Time
  • Organ Size
  • Postoperative Complications / etiology
  • Prostatic Hyperplasia / pathology
  • Prostatic Hyperplasia / surgery*
  • Retrospective Studies
  • Thulium / therapeutic use*
  • Transurethral Resection of Prostate*
  • Treatment Outcome


  • Thulium