Abstract
A peptide-modified gold nanoparticle was developed for tumour-targeted therapy. Triggered by alkaline phosphatase, the CREKA-YPFFK(Nph) peptide can self-assemble and further result in accumulation of gold nanoparticles in tumour cells. The large-sized gold nanoparticle aggregates cannot escape from the tumour tissue, therefore realizing the goal of tumour-specific targeting, enhanced retention and photothermal effects.
MeSH terms
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Alkaline Phosphatase / metabolism
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Amino Acid Sequence
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / radiation effects
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Agents / toxicity
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Cell Line, Tumor
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Gold / chemistry*
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Humans
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Light
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Male
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Metal Nanoparticles / chemistry
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Metal Nanoparticles / radiation effects
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Metal Nanoparticles / therapeutic use*
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Metal Nanoparticles / toxicity
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Mice, Inbred BALB C
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Oligopeptides / chemical synthesis
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Oligopeptides / metabolism
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Oligopeptides / radiation effects
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Oligopeptides / toxicity
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Particle Size
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Phototherapy / methods
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Prostatic Neoplasms / drug therapy*
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Temperature
Substances
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Antineoplastic Agents
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Oligopeptides
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cysteinyl-arginyl-glutamyl-lysyl-alanyl
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Gold
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Alkaline Phosphatase