Rectal application of argan oil improves healing of colorectal anastomosis in rats1

Acta Cir Bras. 2018 Jul;33(7):565-576. doi: 10.1590/s0102-865020180070000002.


Purpose: To investigate the possible effects of argan oil on the healing of colorectal anastomoses.

Methods: n Group 1 (sham), laparotomy was performed and the colon was mobilized. In the control (Group 2) and argan oil (Group 3) groups, colonic resection and anastomosis were applied. To the control and sham groups, 2 mL of 0.9% NaCl was administred rectally, and in the argan oil group, 2 mL/day argan oil was applied rectally for 7 days.

Results: The mean bursting pressures of the argan oil and sham groups were significantly higher than the values in the control group. A significant difference was determined between the tissue hydroxyproline and prolidase levels of control group and other groups. Histopathologically, argan oil showed significant beneficial effects on colonic wound healing. In the argan oil and sham groups, the tissue malondialdehyde and fluorescent oxidation product levels were found to be lower and total sulfhydryl levels were higher than the control group.

Conclusions: The rectally administered argan oil was observed to have significantly ameliorated wound healing parameters and exerted a significant antioxidant effect. This is the first study in the literature about the beneficial effects of argan oil on colorectal anastomoses.

Publication types

  • Evaluation Study

MeSH terms

  • Anastomosis, Surgical
  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Collagen / analysis
  • Colon / pathology
  • Colon / surgery*
  • Dipeptidases / analysis
  • Female
  • Hydroxyproline / analysis
  • Malondialdehyde / analysis
  • Oxidative Stress / drug effects
  • Oxidoreductases / analysis
  • Plant Oils / therapeutic use*
  • Random Allocation
  • Rats, Wistar
  • Rectum / pathology
  • Rectum / surgery*
  • Reproducibility of Results
  • Spectrophotometry
  • Surgical Wound / drug therapy
  • Surgical Wound / pathology
  • Treatment Outcome
  • Wound Healing / drug effects*


  • Anti-Inflammatory Agents
  • Antioxidants
  • Plant Oils
  • argan oil
  • Malondialdehyde
  • Collagen
  • Oxidoreductases
  • sulfhydryl oxidase
  • Dipeptidases
  • proline dipeptidase
  • Hydroxyproline