Melanoma - role of the environment and genetics

Photochem Photobiol Sci. 2018 Dec 5;17(12):1853-1860. doi: 10.1039/c7pp00411g.


Melanoma rates have increased in populations that are mainly European. The main etiologic factor is ultraviolet radiation, from the sun as well as artificial tanning devices. Host factors such as skin color, number of nevi, hair and eye color and tanning ability are critical factors in modifying an individual's response to the sun. Genetic factors interact with host factors and environmental factors to increase risk. This review summarizes our current knowledge of environment and genetics on melanoma risk and on gene-environment interaction.

Publication types

  • Review

MeSH terms

  • Cyclin-Dependent Kinase Inhibitor p18 / genetics
  • DNA Repair
  • Humans
  • Melanoma / etiology*
  • Melanoma / genetics
  • Nevus / etiology
  • Nevus / pathology
  • Receptor, Melanocortin, Type 1 / genetics
  • Risk Factors
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / genetics
  • Tanning
  • Ultraviolet Rays


  • Cyclin-Dependent Kinase Inhibitor p18
  • Receptor, Melanocortin, Type 1