Histopathological differences of experimental aneurysms treated with bare platinum, fibered, and bioactive coils

Minim Invasive Ther Allied Technol. 2019 Jun;28(3):172-177. doi: 10.1080/13645706.2018.1499532. Epub 2018 Aug 16.

Abstract

Purpose: To evaluate the histopathological features of experimental aneurysms embolized with bare platinum, fibered, and bioactive coils.

Material and methods: Twelve experimental aneurysms were constructed in three swine. The aneurysms were divided into four groups and were embolized using a bare platinum coil alone (P group, n = 2), a bioactive coil alone (B group, n = 2), a combination of fibered and bare platinum coils (F/P group, n = 4) and a combination of fibered and bioactive coils (F/B group, n = 4). Histopathological data for all aneurysms recorded at 63 days were analyzed in terms of neointima formation, fibrosis, foreign-body giant-cell infiltration, and organization.

Results: Fibrosis was significantly greater in group B compared with that in group F/P (p = .02). Inflammation with foreign-body giant-cell infiltration was significantly greater in groups F/P and F/B compared with that in groups P and B (p = .007).

Conclusion: The present study revealed that the embolic effect of fibered coils was not a thrombus but instead was a foreign-body response in the chronic phase.

Keywords: Coil embolization; bioactive coil; fibered coil; histopathological features.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Disease Models, Animal
  • Embolization, Therapeutic / methods*
  • Intracranial Aneurysm / therapy*
  • Platinum / chemistry*
  • Swine
  • Thrombosis / pathology
  • Treatment Outcome

Substances

  • Platinum