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Review
. 2018 Sep;159 Suppl 1(Suppl 1):S65-S73.
doi: 10.1097/j.pain.0000000000001329.

A Bright Future? Optogenetics in the Periphery for Pain Research and Therapy

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Free PMC article
Review

A Bright Future? Optogenetics in the Periphery for Pain Research and Therapy

Aaron D Mickle et al. Pain. .
Free PMC article

Figures

Figure 1
Figure 1
Peripheral Light Delivery Technology for Optogenetics. A and B) Wirelessly powered µLED device for stimulation of spinal afferents or spinal cord neurons. Reproduced from reference [95] with permission. C and D) µLED device for illuminating opsins in the bladder or lower abdomen. Additional encapsulation layers provide protection from mechanical forces and repetitive stresses associated with subcutaneous abdominal implants. Reproduced from reference [94] with permission. E) Multi-purpose wireless µLED device that can target opsins expressed in various brain regions and peripheral tissues. Reproduced from reference [100] with permission. F) Illustration of a multi-use wireless µLED device used to target colon afferents. Reproduced from reference [50] with permission. G and D) Demonstration of a nanowire system, for electrical recording and optical stimulation of spinal cord neurons [67].

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