Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 5 (2), 387-97

Multiple Sequence Motifs Are Involved in SV40 Enhancer Function

Multiple Sequence Motifs Are Involved in SV40 Enhancer Function

M Zenke et al. EMBO J.

Abstract

A systematic mutagenesis of the SV40 enhancer indicates that it spans approximately 100 bp and is composed of at least two distinct DNA domains which exhibit very little enhancing activity on their own. Their association results in a 400-fold enhancement of transcription, virtually irrespective of their relative orientation and, to some extent, of the distance between them. Enhancer activity can also be generated by duplication of either domain. We show also that the activity of each domain is due to the presence of several specific sequence motifs. These motifs are found assorted in different combinations in other viral and cellular enhancers.

Similar articles

See all similar articles

Cited by 219 PubMed Central articles

See all "Cited by" articles

References

    1. EMBO J. 1983;2(8):1373-8 - PubMed
    1. Cell. 1984 Dec;39(3 Pt 2):653-62 - PubMed
    1. FEBS Lett. 1976 Dec 1;71(2):313-5 - PubMed
    1. Science. 1978 May 5;200(4341):494-502 - PubMed
    1. Nucleic Acids Res. 1978 Oct;5(10):3635-42 - PubMed

Publication types

Substances

LinkOut - more resources

Feedback