Abolishment of inhibitory effects of 3'-deazaadenosine on superoxide generation of guinea pig phagocytes by pre-exposure to phorbol myristate acetate

FEBS Lett. 1986 Jun 9;201(2):287-90. doi: 10.1016/0014-5793(86)80625-1.

Abstract

Superoxide generation by guinea pig macrophages and polymorphonuclear leukocytes induced by wheat germ agglutinin, immune complexes or formyl-methionyl-leucyl-phenylalanine was inhibited considerably by 3'-deazaadenosine. The pre-exposure of the 3'-dezazaadenosine-treated cells to a small amount of phorbol myristate acetate abolished the inhibitory effect of 3'-deazaadenosine on the generation of superoxide.

MeSH terms

  • Animals
  • Antigen-Antibody Complex
  • Dose-Response Relationship, Drug
  • Guinea Pigs
  • Lectins / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • N-Formylmethionine Leucyl-Phenylalanine / pharmacology
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Phagocytes / drug effects
  • Phagocytes / metabolism*
  • Phorbols / pharmacology*
  • Ribonucleosides / pharmacology*
  • Superoxides / metabolism*
  • Tetradecanoylphorbol Acetate / pharmacology*
  • Tubercidin / pharmacology*
  • Wheat Germ Agglutinins

Substances

  • Antigen-Antibody Complex
  • Lectins
  • Phorbols
  • Ribonucleosides
  • Wheat Germ Agglutinins
  • 3-deazaadenosine
  • Superoxides
  • N-Formylmethionine Leucyl-Phenylalanine
  • Tubercidin
  • Tetradecanoylphorbol Acetate