Splenomegaly: A Combined Clinical and Radiologic Approach to the Differential Diagnosis

Gastroenterol Clin North Am. 2018 Sep;47(3):643-666. doi: 10.1016/j.gtc.2018.04.009. Epub 2018 Jul 7.


An enlarged spleen (splenomegaly) is a common imaging finding and may be related to a broad array of underlying conditions. The multifaceted functions of the spleen make it susceptible to involvement by a variety of pathophysiologic processes. Understanding these conditions and incorporating all relevant clinical and radiologic data allow narrowing the differential diagnosis.

Keywords: CT; Spleen; Splenomegaly.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Spleen / diagnostic imaging
  • Spleen / pathology*
  • Splenomegaly / diagnosis*
  • Splenomegaly / etiology