Symptoms, Mobility and Function, and Quality of Life in Adults With Acute Leukemia During Initial Hospitalization

Oncol Nurs Forum. 2018 Sep 1;45(5):653-664. doi: 10.1188/18.ONF.653-664.


Objectives: To examine longitudinal symptoms, mobility and function, and quality of life (QOL) in adults newly diagnosed with acute leukemia.

Sample & setting: 55 adults undergoing induction chemotherapy at the University of North Carolina Lineberger Comprehensive Cancer Center and the Duke Cancer Institute.

Methods & variables: A prospective, longitudinal study with measures of mobility and function, global physical and mental health, cancer-related fatigue, anxiety, depression, sleep disturbance, pain intensity, and leukemia-specific QOL was conducted. Data were analyzed using descriptive statistics, linear mixed modeling, and one-way analysis of variance.

Results: 49 adults with acute leukemia completed assessments during hospitalizations. Global mental health and pain intensity did not change significantly. Global physical health significantly improved. Fatigue, anxiety, depression, and sleep disturbance decreased significantly. QOL increased significantly.

Implications for nursing: The significant decrease in anxiety and fatigue during hospitalization may be attributable to understanding of the disease process, familiarity with the staff, and ability to communicate concerns.

Keywords: PROMIS; acute leukemia; function; hospitalization; mobility; quality of life; symptoms.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents / therapeutic use*
  • Behavioral Symptoms / psychology*
  • Female
  • Hospitalization
  • Humans
  • Inpatients / psychology*
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / psychology*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Mobility Limitation*
  • North Carolina
  • Prospective Studies
  • Quality of Life / psychology*
  • Young Adult


  • Antineoplastic Agents